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Article

Polymorphism and regulation of the spxB (pyruvate oxidase) virulence factor gene by a CBS-HotDog domain protein (SpxR) in serotype 2 Streptococcus pneumoniae.

Molecular microbiology - 1 Feb 2008

Ramos-Montañez Smirla, Tsui Ho-Ching Tiffany, Wayne Kyle J, Morris Jordan L, Peters Lindsey E, Zhang Faming, Kazmierczak Krystyna M, Sham Lok-To, Winkler Malcolm E

Abstract excerpt

spxB-encoded pyruvate oxidase is a major virulence factor of Streptococcus pneumoniae. During aerobic growth, SpxB synthesizes H2O2 and acetyl phosphate, which play roles in metabolism, signalling, and oxidative stress. We report here the first cis- and trans-acting regulatory elements for spxB t...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 18179423
DOI: 10.1111/j.1365-2958.2007.06082.x

Genes

CBS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18179423-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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