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Article

RAS mutations are the predominant molecular alteration in poorly differentiated thyroid carcinomas and bear prognostic impact.

The Journal of clinical endocrinology and metabolism - 1 Dec 2009

Volante Marco, Rapa Ida, Gandhi Manoj, Bussolati Gianni, Giachino Daniela, Papotti Mauro, Nikiforov Yuri E

Abstract excerpt

CONTEXT: Poorly differentiated carcinomas represent an aggressive group of thyroid tumors with controversial classification placement and poorly understood pathogenesis. Molecular data in this group of tumors are extremely heterogeneous, possibly reflecting different inclusion criteria. Recently homogeneous diagnostic criteria have been proposed by our group (Turin proposal) that need to be complemented by...

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Source

Identifiers

PMID: 19837916
DOI: 10.1210/jc.2009-1233

Genes

BRAF
PAX8
RET
HRAS
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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