Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Contribution of endosomal acidification to antigen processing.

Seminars in immunology - 1 Jul 1990

McCoy K L

Abstract excerpt

The role of endosomes in antigen processing was investigated with mutant cells, expressing a temperature-sensitive defect in endosomal acidification, as a source of antigen-presenting cells for CD4+ T cell responses. When the mutants were incubated at the nonpermissive temperature, their ability to process a variety of native antigens was greatly impaired. These cells could present peptide fragments normally, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen-Presenting Cells
Share to Endocytosis
Share to Endosomes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class II

Share to Hydrogen-Ion Concentration

Share to Mutation

Source

Identifiers

PMID: 1983337

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Contribution of endosomal acidification to antigen processing.PMID 1983337Read ↗

Sindbis virus infection of a Chinese hamster ovary cell mutant defective in the acidification of endosomes.Semantic proximity Read ↗

Biosynthesis of lysosomal enzymes in cells of the End3 complementation group conditionally defective in endosomal acidification.Semantic proximity Read ↗

A West Nile virus mutant with increased resistance to acid-induced inactivationSemantic proximity Read ↗

Recovery of function in Chinese hamster ovary cell mutants with temperature-sensitive defects in vacuolar acidification.Semantic proximity Read ↗

Peptide transporter-independent, stress protein-mediated endosomal processing of endogenous protein antigens for major histocompatibility complex class I presentation.Semantic proximity Read ↗

Modulation of dendritic cell endocytosis and antigen processing pathways by Escherichia coli heat-labile enterotoxin and mutant derivatives.Semantic proximity Read ↗

Transport and expression of class I MHC glycoproteins in an antigen-processing mutant cell line.Semantic proximity Read ↗

Lysosome-Related Organelles: A View from Immunity and Pigmentation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.