Contribution of endosomal acidification to antigen processing.

Article

Contribution of endosomal acidification to antigen processing.

Seminars in immunology - 1 Jul 1990

McCoy K L

Abstract excerpt

The role of endosomes in antigen processing was investigated with mutant cells, expressing a temperature-sensitive defect in endosomal acidification, as a source of antigen-presenting cells for CD4+ T cell responses. When the mutants were incubated at the nonpermissive temperature, their ability...

Topics

Animals
Antigen-Presenting Cells
Endocytosis
Endosomes
Histocompatibility Antigens Class II
Hydrogen-Ion Concentration
Mutation

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