Article
Postoperative fibromatosis-type fibromas in the Bhd gene mutant (Nihon) rat.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie - 1 Mar 2008
Kouchi Mami, Okimoto Kazuo, Matsumoto Izumi, Michimae Yoshiko, Yamada Toru, Inoue Tadashi, Kimura Toru, Seki Takaki, Yasuba Masashi, Hino Okio
Abstract excerpt
Fibromatosis-type fibromas were found to develop at abdominal surgical sites in 4 heterozygous Nihon rats, a model for the human Birt-Hogg-Dubé syndrome. In all 4 rats, solitary and firm nodules were located within the lateral abdominal musculature involving the full thickness of the abdominal wall at the sites of laparotomy. Histologically, the nodules consisted of well-differentiated fibroblastic spindle-shaped...
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