Postoperative fibromatosis-type fibromas in the Bhd gene mutant (Nihon) rat.

doi:10.1016/j.etp.2007.10.005

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Article

Postoperative fibromatosis-type fibromas in the Bhd gene mutant (Nihon) rat.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie - 1 Mar 2008

Kouchi Mami, Okimoto Kazuo, Matsumoto Izumi, Michimae Yoshiko, Yamada Toru, Inoue Tadashi, Kimura Toru, Seki Takaki, Yasuba Masashi, Hino Okio

Abstract excerpt

Fibromatosis-type fibromas were found to develop at abdominal surgical sites in 4 heterozygous Nihon rats, a model for the human Birt-Hogg-Dubé syndrome. In all 4 rats, solitary and firm nodules were located within the lateral abdominal musculature involving the full thickness of the abdominal wall at the sites of laparotomy. Histologically, the nodules consisted of well-differentiated fibroblastic spindle-shaped...

Topics

Animals
Disease Models, Animal
Fibroma
Laparotomy
Mutation
Proteins
Rats
Rats, Mutant Strains

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Open in PubMed

Identifiers

PMID: 18036795
DOI: 10.1016/j.etp.2007.10.005

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