Article
Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance.
The Journal of biological chemistry - 11 Dec 2009
Das Kalyan, Bandwar Rajiv P, White Kirsten L, Feng Joy Y, Sarafianos Stefan G, Tuske Steven, Tu Xiongying, Clark Arthur D, Boyer Paul L, Hou Xiaorong, Gaffney Barbara L, Jones Roger A, Miller Michael D, Hughes Stephen H, Arnold Eddy
Abstract excerpt
K65R is a primary reverse transcriptase (RT) mutation selected in human immunodeficiency virus type 1-infected patients taking antiretroviral regimens containing tenofovir disoproxil fumarate or other nucleoside analog RT drugs. We determined the crystal structures of K65R mutant RT cross-linked to double-stranded DNA and in complexes with tenofovir diphosphate (TFV-DP) or dATP. The crystals permit substitution...
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