Article
Impaired p53 function leads to centrosome amplification, acquired ERalpha phenotypic heterogeneity and distant metastases in breast cancer MCF-7 xenografts.
Oncogene - 26 Jun 2008
D'Assoro A B, Busby R, Acu I D, Quatraro C, Reinholz M M, Farrugia D J, Schroeder M A, Allen C, Stivala F, Galanis E, Salisbury J L
Abstract excerpt
In this study, we establish an MCF-7 xenograft model that mimics the progression of human breast carcinomas typified by loss of p53 integrity, development of centrosome amplification, acquired estrogen receptor (ERalpha) heterogeneity, overexpression of Mdm2 and metastatic spread from the primary tumor to distant organs. MCF-7 cells with abrogated p53 function (vMCF-7(Dnp53)) maintained nuclear ERalpha expression...
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