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Article

Control by Circulating Factors of Mitochondrial Function and Transcription Cascade in Heart Failure

9 May 2009

Abstract excerpt

BACKGROUND: Evidence is emerging to support the concept that the failing heart is "energy depleted" and that defects in energy metabolism are important determinants in the development and the progression of the disease. We have shown previously that depressed mitochondrial function in cardiac and skeletal muscles in chronic heart failure is linked to decreased expression of the gene encoding transcriptional...

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Identifiers

PMID: 19808358
DOI: 10.1161/circheartfailure.108.812099

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