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Article

Defective DNA Replication Impairs Mitochondrial Biogenesis In Human Failing Hearts

26 Mar 2010

Abstract excerpt

RATIONALE: Mitochondrial dysfunction plays a pivotal role in the development of heart failure. Animal studies suggest that impaired mitochondrial biogenesis attributable to downregulation of the peroxisome proliferator-activated receptor gamma coactivator (PGC)-1 transcriptional pathway is integral of mitochondrial dysfunction in heart failure. OBJECTIVE: The study sought to define mechanisms underlying the...

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Identifiers

PMID: 20339121
DOI: 10.1161/circresaha.109.212753

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