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Article

An evolutionary conserved function of the JAK-STAT pathway in anti-dengue defense

1 Oct 2009

Abstract excerpt

Here, we show that the major mosquito vector for dengue virus uses the JAK-STAT pathway to control virus infection. Dengue virus infection in Aedes aegypti mosquitoes activates the JAK-STAT immune signaling pathway. The mosquito's susceptibility to dengue virus infection increases when the JAK-STAT pathway is suppressed through RNAi depletion of its receptor Domeless (Dome) and the Janus kinase (Hop), whereas...

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PMID: 19805194
DOI: 10.1073/pnas.0905006106

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