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Article

Characterization of Aedes aegypti Innate-Immune Pathways that Limit Chikungunya Virus Replication

24 Jul 2014

Abstract excerpt

Replication of arboviruses in their arthropod vectors is controlled by innate immune responses. The RNA sequence-specific break down mechanism, RNA interference (RNAi), has been shown to be an important innate antiviral response in mosquitoes. In addition, immune signaling pathways have been reported to mediate arbovirus infections in mosquitoes; namely the JAK/STAT, immune deficiency (IMD) and Toll pathways....

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PMID: 25058001
DOI: 10.1371/journal.pntd.0002994

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