Article
CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1.
Proceedings of the National Academy of Sciences of the United States of America - 13 Oct 2009
Yoon Kyoung Wan, Cho Jun-Ho, Lee Jae Keun, Kang Young-Hee, Chae Ji Soo, Kim Young Mok, Kim Jeehyun, Kim Eun Kyung, Kim Sung Eun, Baik Ja-Hyun, Naik Ulhas P, Cho Ssang-Goo, Choi Eui-Ju
Abstract excerpt
Calcium and integrin binding protein 1 (CIB1) is a Ca(2+)-binding protein of 22 kDa that was initially identified as a protein that interacts with integrin alpha(IIb). Although it interacts with various proteins and has been implicated in diverse cellular functions, the molecular mechanism by which CIB1 regulates intracellular signaling networks has remained unclear. We now show that, by targeting apoptosis...
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