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Article

AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.

The Journal of biological chemistry - 22 Oct 2004

Zhang Haifeng, Zhang Rong, Luo Yan, D'Alessio Alessio, Pober Jordan S, Min Wang

Abstract excerpt

Previously we have shown that ASK-interacting protein 1 (AIP1, also known as DAB2IP), a novel member of the Ras-GAP protein family, mediates TNF-induced activation of ASK1-JNK signaling pathway. However, the mechanism by which TNF signaling is coupled to AIP1 is not known. Here we show that AIP1 is localized on the plasma membrane in resting endothelial cells (EC) in a complex with TNFR1. TNF binding induces...

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Source

Identifiers

PMID: 15310755
DOI: 10.1074/jbc.M407617200

Genes

TRAF2
TNF
TRADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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