Article
Primary structure of the gene coding for the haemagglutinin of influenza virus A/Leningrad/385/80(H3N2): detection of a point mutation responsible for the antigenic drift.
Acta virologica - 1 May 1990
Migunova B V, Plusnin A Z, Petrov N A, Rivkin M I, Grinbaum E B, Obuchova L V, Kuznetzov O K
Abstract excerpt
Primary structure of the gene coding for haemagglutinin (HA-gene) of influenza virus A/Leningrad/385/80(H2N2) isolated during the epidemics of influenza in Leningrad in 1980 was determined. The close relationship of HA gene of this virus to the corresponding gene of the virus A/Bangkok/1/79(H3N2) was confirmed. It was shown that a single mutation in an antigenic site (the change from isoleucine to leucine at...
Topics
- Amino Acid Sequence
- Antigenic Variation
- Base Sequence
- Biological Evolution
- DNA, Viral
- Gene Frequency
- Genes, Viral
- Hemagglutinin Glycoproteins, Influenza Virus
- Hemagglutinins, Viral
- Humans