Article
Susceptibility to urinary bladder cancer: relevance of rs9642880[T], GSTM1 0/0 and occupational exposure.
Pharmacogenetics and genomics - 1 Nov 2009
Golka Klaus, Hermes Matthias, Selinski Silvia, Blaszkewicz Meinolf, Bolt Hermann M, Roth Gerhard, Dietrich Holger, Prager Hans-Martin, Ickstadt Katja, Hengstler Jan G
Abstract excerpt
Recently, a genome-wide single nucleotide polymorphism association study has identified a sequence variant 30 kb upstream of the c-Myc gene (allele T of rs9642880) that confers susceptibility to bladder cancer. However, the role of exposure to bladder carcinogens has not been considered. This prompted us to analyse the relevance of this polymorphism in 515 bladder cancer cases and 893 controls where the quality...
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