Modification of Occupational Exposures on Bladder Cancer Risk by Common Genetic Polymorphisms.

doi:10.1093/jnci/djv223

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Article

Modification of Occupational Exposures on Bladder Cancer Risk by Common Genetic Polymorphisms.

Journal of the National Cancer Institute - 1 Nov 2015

Figueroa Jonine D, Koutros Stella, Colt Joanne S, Kogevinas Manolis, Garcia-Closas Montserrat, Real Francisco X, Friesen Melissa C, Baris Dalsu, Stewart Patricia, Schwenn Molly, Johnson Alison, Karagas Margaret R, Armenti Karla R, Moore Lee E, Schned Alan, Lenz Petra, Prokunina-Olsson Ludmila, Banday A Rouf, Paquin Ashley, Ylaya Kris, Chung Joon-Yong, Hewitt Stephen M, Nickerson Michael L, Tardón Adonina, Serra Consol, Carrato Alfredo, García-Closas Reina, Lloreta Josep, Malats Núria, Fraumeni Joseph F, Chanock Stephen J, Chatterjee Nilanjan, Rothman Nathaniel, Silverman Debra T

Abstract excerpt

Few studies have demonstrated gene/environment interactions in cancer research. Using data on high-risk occupations for 2258 case patients and 2410 control patients from two bladder cancer studies, we observed that three of 16 known or candidate bladder cancer susceptibility variants displayed statistically significant and consistent evidence of additive interactions; specifically, the GSTM1 deletion polymorphism...

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Identifiers

PMID: 26374428
DOI: 10.1093/jnci/djv223
PMCID: PMC4675099

Genes

FGFR3
TACC3
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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