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Article

Defects in auxiliary redox proteins lead to functional methionine synthase deficiency.

The Journal of biological chemistry - 1 Aug 1997

Gulati S, Chen Z, Brody L C, Rosenblatt D S, Banerjee R

Abstract excerpt

Methionine synthase catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to form methionine and tetrahydrofolate and is dependent on methylcobalamin, a derivative of vitamin B12, for activity. Due to the lability of the intermediate, cob(I)alamin, the activity of methionine synthase is additionally dependent on a redox activation system. In bacteria, two flavoproteins, NADPH-flavodoxin...

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Identifiers

PMID: 9235907
DOI: 10.1074/jbc.272.31.19171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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