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Article

The Toxin-Antitoxin System of the Streptococcal Plasmid pSM19035

18 Aug 2005

Abstract excerpt

pSM19035 of the pathogenic bacterium Streptococcus pyogenes is a low-copy-number plasmid carrying erythromycin resistance, stably maintained in a broad range of gram-positive bacteria. We show here that the omega-epsilon-zeta operon of this plasmid constitutes a novel proteic plasmid addiction system in which the epsilon and zeta genes encode an antitoxin and toxin, respectively, while omega plays an...

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PMID: 16109951
DOI: 10.1128/jb.187.17.6094-6105.2005

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