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Article

Inhibition of tumor necrosis factor-induced phenotypes by short intracellular versions of latent membrane protein-1.

Cellular signalling - 1 Feb 2010

Ndour Papa Alioune, Ouk Tan-Sothéa, Brocqueville Guillaume, Mougel Alexandra, Vanhecke Elsa, Feuillard Jean, Coll Jean, Adriaenssens Eric

Abstract excerpt

Tumor necrosis factor (TNF) is a potent multi-functional cytokine with a homeostatic role in host defence. In case of deregulation, TNF is implicated in numerous pathologies. The latent membrane protein-1 (LMP1) is expressed by Epstein-Barr virus during viral latency and displaying properties of a constitutively activated member of the TNF receptor family. Both TNFR1 and LMP1 share a similar set of proximal...

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Source

Identifiers

PMID: 19796681
DOI: 10.1016/j.cellsig.2009.09.037

Genes

TNF
TRADD
TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Inhibition of tumor necrosis factor-induced phenotypes by short intracellular versions of latent membrane protein-1.PMID 19796681Read ↗

A novel dominant-negative mutant form of Epstein-Barr virus latent membrane protein-1 (LMP1) selectively and differentially impairs LMP1 and TNF signaling pathways.Semantic proximity Read ↗

The Viral Oncoprotein LMP1 Exploits TRADD for Signaling by Masking Its Apoptotic ActivitySemantic proximity Read ↗

Analysis of human tumour necrosis factor receptor 1 dominant-negative mutants reveals a major region controlling cell surface expression.Semantic proximity Read ↗

The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-kappa B and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain.Semantic proximity Read ↗

LMP1 signal transduction differs substantially from TNF receptor 1 signaling in the molecular functions of TRADD and TRAF2.Semantic proximity Read ↗

Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-kappaB through a pathway that includes the NF-kappaB-inducing kinase and the IkappaB kinases IKKalpha and IKKbeta.Semantic proximity Read ↗

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Functionally significant mutations in the Epstein-Barr virus LMP1 gene and their role in activation of cell signaling pathways.Semantic proximity Read ↗

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Mutation of the extracellular domain of tumour necrosis factor receptor 1 causes reduced NF‐κB activation due to decreased surface expressionSemantic proximity Read ↗

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