Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The NOTCH Ligand JAG1 Regulates GDNF Expression in Sertoli Cells

4 Jan 2017

Abstract excerpt

In the seminiferous epithelium of the testis, Sertoli cells are key niche cells directing proliferation and differentiation of spermatogonial stem cells (SSCs) into spermatozoa. Sertoli cells produce glial cell line-derived neurotrophic factor (GDNF), which is essential for SSC self-renewal and progenitor expansion. While the role of GDNF in the testis stem cell niche is established, little is known about how...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28051360
DOI: 10.1089/scd.2016.0318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The NOTCH Ligand JAG1 Regulates GDNF Expression in Sertoli CellsPMID 28051360Read ↗

RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell nicheSemantic proximity Read ↗

Regulation of GDNF expression in Sertoli cellsSemantic proximity Read ↗

Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence.Semantic proximity Read ↗

Sertoli Cell-Germ Cell Interactions Within the Niche: Paracrine and Juxtacrine Molecular CommunicationsSemantic proximity Read ↗

NOTCH signaling in Sertoli cells regulates gonocyte fateSemantic proximity Read ↗

Expression regulation and function of heparan sulfate 6-O-endosulfatases in the spermatogonial stem cell nicheSemantic proximity Read ↗

Gdnf signaling pathways within the mammalian spermatogonial stem cell nicheSemantic proximity Read ↗

The production of glial cell line-derived neurotrophic factor by human sertoli cells is substantially reduced in sertoli cell-only testesSemantic proximity Read ↗

Gdnf Acts as a Germ Cell-Derived Growth Factor and Regulates the Zebrafish Germ Stem Cell Niche in Autocrine- and Paracrine-Dependent MannersSemantic proximity Read ↗

Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis.Semantic proximity Read ↗

NANOS2 Acts Downstream of Glial Cell Line-Derived Neurotrophic Factor Signaling to Suppress Differentiation of Spermatogonial Stem CellsSemantic proximity Read ↗

The Luteinizing Hormone-Testosterone Pathway Regulates Mouse Spermatogonial Stem Cell Self-Renewal by Suppressing WNT5A Expression in Sertoli Cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.