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Article

Developmental defects in brain segmentation caused by mutations of the homeobox genes orthodenticle and empty spiracles in Drosophila.

Neuron - 1 Oct 1995

Hirth F, Therianos S, Loop T, Gehring W J, Reichert H, Furukubo-Tokunaga K

Abstract excerpt

We have studied the roles of the homeobox genes orthodenticle (otd) and empty spiracles (ems) in embryonic brain development of Drosophila. The embryonic brain is composed of three segmental neuromeres. The otd gene is expressed predominantly in the anterior neuromere; expression of ems is restricted to the two posterior neuromeres. Mutation of otd eliminates the first (protocerebral) brain neuromere. Mutation of...

Topics

Animals
Brain
Drosophila
Drosophila Proteins
Gene Expression
Genes, Homeobox
Homeodomain Proteins
Immunoenzyme Techniques
Mutation
Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7576627
DOI: 10.1016/0896-6273(95)90169-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7576627-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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