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Article

Nuclear NF-kappaB p65 phosphorylation at serine 276 by protein kinase A contributes to the malignant phenotype of head and neck cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2009

Arun Pattatheyil, Brown Matthew S, Ehsanian Reza, Chen Zhong, Van Waes Carter

Abstract excerpt

PURPOSE: Aberrant nuclear activation and phosphorylation of the canonical NF-kappaB subunit RELA/p65 at Serine-536 by inhibitor kappaB kinase is prevalent in head and neck squamous cell carcinoma (HNSCC), but the role of other kinases in NF-kappaB activation has not been well defined. Here, we investigated the prevalence and function of p65-Ser276 phosphorylation by protein kinase A (PKA) in the malignant...

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Source

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Identifiers

PMID: 19789307
DOI: 10.1158/1078-0432.CCR-09-1352
PMCID: PMC2760015

Genes

TNF
BCL2
RELA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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