The mutation for medullary thyroid carcinoma with parathyroid tumors (MTC with PTs) is closely linked to the centromeric region of chromosome 10.

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Article

The mutation for medullary thyroid carcinoma with parathyroid tumors (MTC with PTs) is closely linked to the centromeric region of chromosome 10.

American journal of human genetics - 1 Dec 1990

Carson N L, Wu J S, Jackson C E, Kidd K K, Simpson N E

Abstract excerpt

Two new morphs (F and G) detected by the centromeric alpha satellite probe p alpha 10RP8 and D10Z1 in HinfI digests are linked to the PstI polymorphisms of D10Z1, confirming their chromosome 10 location. The F and G morphs were in strong linkage disequilibrium with each other but were in weak linkage disequilibrium with the A and B morphs defined in PstI digests. Data for haplotypes formed by using the A and F...

Topics

Adrenal Gland Neoplasms
Alleles
Centromere
Chromosomes, Human, Pair 10
Female
Genetic Linkage
Haplotypes
Humans
Linkage Disequilibrium
Male
Multiple Endocrine Neoplasia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Parathyroid Neoplasms

Phenotype

Pheochromocytoma

Polymorphism, Restriction Fragment Length

Thyroid Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 1978560
PMCID: PMC1683917

Genes

RBP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1978560-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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