Article
Mutations in the external loops of BK virus VP1 and urine viral load in renal transplant recipients.
Journal of cellular physiology - 1 Jan 2010
Tremolada Sara, Delbue Serena, Castagnoli Lorenzo, Allegrini Sara, Miglio Umberto, Boldorini Renzo, Elia Francesca, Gordon Jennifer, Ferrante Pasquale
Abstract excerpt
Polyomavirus-associated nephropathy (PVAN) is a major complication that occurs after renal transplantation and is induced by reactivation of the human polyomavirus BK (BKV). The structure of the viral capsid protein 1 (VP1) is characterized by the presence of external loops, BC, DE, EF, GH, and HI, which are involved in receptor binding. The pathogenesis of PVAN is not well understood, but viral risk factors are...
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