Article
Mutations in the BC-loop of the BKV VP1 region do not influence viral load in renal transplant patients.
Journal of medical virology - 1 Jan 2009
Krautkrämer Ellen, Klein Theresa M, Sommerer C, Schnitzler Paul, Zeier Martin
Abstract excerpt
The reactivation and replication of the BK polyomavirus (BKV) leading to BKV-associated nephropathy (BKVAN) is one of the major complications in renal transplantation patients. BKV isolates were classified into four subtypes (I-IV) based on genotype variations within the VP1-coding region. The type-specific amino acid differences cluster within the BC-loop of the major capsid protein VP1. As demonstrated in...
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