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Article

Analysis of nitric oxide metabolism as a placental or maternal factor underlying the etiology of pre-eclampsia.

Gynecologic and obstetric investigation - 1 Jan 2009

Nishizawa Haruki, Pryor-Koishi Kanako, Suzuki Machiko, Kato Takema, Sekiya Takao, Tada Shin, Kurahashi Hiroki, Udagawa Yasuhiro

Abstract excerpt

BACKGROUND: Defective nitric oxide (NO)-mediated vasodilation is widely regarded as an underlying cause of hypertension in pre-eclampsia, although there are also arguments against this hypothesis. METHODS: We examined both the mRNA levels and the presence of a Glu298Asp substitution in the NO synthase (NOS) gene, as well as the NO metabolite concentration, in placentas and maternal sera from women with...

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PMID: 19776611
DOI: 10.1159/000238381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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