The genetic basis for systemic lupus erythematosus.

Abstract excerpt

Genetic factors play a major role in the development of lupus. More than 5% of cases are familial, and the concordance rate between identical twins is 40%. Genetic studies in mice suggest a complex mechanism of transmission involving interactions among several susceptibility genes and, probably, protective genes. Genetic studies in humans have identified nearly 50 chromosomal areas possibly involved in lupus...

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