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Article

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera.

Nature - 28 Apr 2005

James Chloé, Ugo Valérie, Le Couédic Jean-Pierre, Staerk Judith, Delhommeau François, Lacout Catherine, Garçon Loïc, Raslova Hana, Berger Roland, Bennaceur-Griscelli Annelise, Villeval Jean Luc, Constantinescu Stefan N, Casadevall Nicole, Vainchenker William

Abstract excerpt

Myeloproliferative disorders are clonal haematopoietic stem cell malignancies characterized by independency or hypersensitivity of haematopoietic progenitors to numerous cytokines. The molecular basis of most myeloproliferative disorders is unknown. On the basis of the model of chronic myeloid leukaemia, it is expected that a constitutive tyrosine kinase activity could be at the origin of these diseases....

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Source

Identifiers

PMID: 15793561
DOI: 10.1038/nature03546

Genes

JAK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera.PMID 15793561Read ↗

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