Additive effects of drug transporter genetic polymorphisms on irinotecan pharmacokinetics/pharmacodynamics in Japanese cancer patients.

doi:10.1007/s00280-009-1138-y

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Article

Additive effects of drug transporter genetic polymorphisms on irinotecan pharmacokinetics/pharmacodynamics in Japanese cancer patients.

Cancer chemotherapy and pharmacology - 1 May 2010

Sai Kimie, Saito Yoshiro, Maekawa Keiko, Kim Su-Ryang, Kaniwa Nahoko, Nishimaki-Mogami Tomoko, Sawada Jun-ichi, Shirao Kuniaki, Hamaguchi Tetsuya, Yamamoto Noboru, Kunitoh Hideo, Ohe Yuichiro, Yamada Yasuhide, Tamura Tomohide, Yoshida Teruhiko, Matsumura Yasuhiro, Ohtsu Atsushi, Saijo Nagahiro, Minami Hironobu

Abstract excerpt

PURPOSE: Effects of genetic polymorphisms/variations of ABCB1, ABCC2, ABCG2 and SLCO1B1 in addition to "UGT1A1*28 or *6" on irinotecan pharmacokinetics/pharmacodynamics in Japanese cancer patients were investigated. METHODS: Associations between transporter haplotypes/variations along with UGT1A1*28 or *6 and SN-38 area under the time-concentration curve (AUC) or neutropenia were examined in irinotecan...

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Identifiers

PMID: 19771428
DOI: 10.1007/s00280-009-1138-y

Genes

ABCB1
ABCG2
ABCC2

Variants

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