The specific binding of nuclear protein(s) to the cAMP responsive element (CRE) sequence (TGACGTCA) is reduced by the misincorporation of U and increased by the deamination of C.

doi:10.1093/nar/18.19.5775

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The specific binding of nuclear protein(s) to the cAMP responsive element (CRE) sequence (TGACGTCA) is reduced by the misincorporation of U and increased by the deamination of C.

Nucleic acids research - 11 Oct 1990

Verri A, Mazzarello P, Biamonti G, Spadari S, Focher F

Abstract excerpt

Point mutations in the cAMP-responsive element (CRE) of the rat somatostatin gene promoter/enhancer sequence (TGACGTCA) were used as a model for assessing the effect of uracil, deriving either from misincorporation during DNA synthesis (T----U) or cytosine deamination (C----U), on the binding of sequence/specific regulatory proteins. The results show that the T----U conversion in both strands of the CRE...

Topics

Animals
Base Composition
Base Sequence
Binding, Competitive
Cyclic AMP
Cytosine
Enhancer Elements, Genetic
HeLa Cells
Humans
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Rats

Regulatory Sequences, Nucleic Acid

Repetitive Sequences, Nucleic Acid

Somatostatin

Uracil

Source

Open in PubMed Open full text

Identifiers

PMID: 1977136
DOI: 10.1093/nar/18.19.5775
PMCID: PMC332313

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1977136-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

The specific binding of nuclear protein(s) to the cAMP responsive element (CRE) sequence (TGACGTCA) is reduced by the misincorporation of U and increased by the deamination of C.PMID 1977136Read ↗

The CRE-like element inside the 5'-upstream region of the rat sodium/iodide symporter gene interacts with diverse classes of b-Zip molecules that regulate transcriptional activities through strong synergy with Pax-8.Semantic proximity Read ↗

Effects of mutation of the CREB binding site of the somatostatin promoter on cyclic AMP responsiveness in CV-1 cells.Semantic proximity Read ↗

Characterization of three different elements in the 5'-flanking region of the fibronectin gene which mediate a transcriptional response to cAMP.Semantic proximity Read ↗

In vivo monitoring of a cAMP-stimulated DNA-binding activity.Semantic proximity Read ↗

A transcriptional repressor obtained by alternative translation of a trinucleotide repeat.Semantic proximity Read ↗

DNA Modifications: Naturally More Error Prone?Semantic proximity Read ↗

Functional cooperation between CREM and GCNF directs gene expression in haploid male germ cellsSemantic proximity Read ↗

C-to-U editing and site-directed RNA editing for the correction of genetic mutationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.