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Article

Analysis of SDF-1/CXCR4 signaling in primordial germ cell migration and survival or differentiation in Xenopus laevis.

Mechanisms of development - 1 Jan 2000

Takeuchi Tomoyo, Tanigawa Yoko, Minamide Ryohei, Ikenishi Kohji, Komiya Tohru

Abstract excerpt

Directional migration of primordial germ cells (PGCs) toward future gonads is a common feature in many animals. In zebrafish, mouse and chicken, SDF-1/CXCR4 chemokine signaling has been shown to have an important role in PGC migration. In Xenopus, SDF-1 is expressed in several regions in embryos including dorsal mesoderm, the target region that PGCs migrate to. CXCR4 is known to be expressed in PGCs. This...

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Share to Cell Movement
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Share to Chemokine CXCL12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

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Source

Identifiers

PMID: 19770040
DOI: 10.1016/j.mod.2009.09.005

Genes

CXCR4
PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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