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Article

The C-X-C signalling system in the rodent vs primate testis: impact on germ cell niche interaction

8 Feb 2018

Abstract excerpt

Abstract In zebrafish, action of the chemokine Cxcl12 is mediated through its G-protein-coupled seven-transmembrane domain receptor Cxcr4 and the atypical receptor Cxcr7. Employing this animal model, it was revealed that this Cxcl12 signalling system plays a crucial role for directed migration of primordial germ cells (PGC) during early testicular development. Importantly, subsequent studies indicated that this...

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PMID: 29420253
DOI: 10.1530/rep-17-0617

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