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Article

Guidance of primordial germ cell migration by the chemokine SDF-1.

Cell - 27 Nov 2002

Doitsidou Maria, Reichman-Fried Michal, Stebler Jürg, Köprunner Marion, Dörries Julia, Meyer Dirk, Esguerra Camila V, Leung TinChung, Raz Erez

Abstract excerpt

The signals directing primordial germ cell (PGC) migration in vertebrates are largely unknown. We demonstrate that sdf-1 mRNA is expressed in locations where PGCs are found and toward which they migrate in wild-type as well as in mutant embryos in which PGC migration is abnormal. Knocking down SDF-1 or its receptor CXCR4 results in severe defects in PGC migration. Specifically, PGCs that do not receive the SDF-1...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12464177
DOI: 10.1016/s0092-8674(02)01135-2

Genes

PGC
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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