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Article

Human-specific induction of glutathione peroxidase-3 by proteasome inhibition in cardiovascular cells.

Free radical biology & medicine - 1 Dec 2009

Westphal Kera, Stangl Verena, Fähling Michael, Dreger Henryk, Weller Andrea, Baumann Gert, Stangl Karl, Meiners Silke

Abstract excerpt

Glutathione peroxidase-3 (GPx-3) is a key antioxidant enzyme in the plasma. GPx-3 was previously identified as the major antioxidative enzyme that was induced upon nontoxic proteasome inhibition in endothelial cells. Here, we investigated the determinants of the proteasome inhibitor-induced expression of GPx-3. Nontoxic proteasome inhibition massively upregulates GPx-3 RNA and protein in human umbilical cord vein...

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Identifiers

PMID: 19766714
DOI: 10.1016/j.freeradbiomed.2009.09.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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