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Article

Complex contributions of Ets2 to craniofacial and thymus phenotypes of trisomic "Down syndrome" mice.

American journal of medical genetics. Part A - 1 Oct 2009

Hill Cheryl A, Sussan Thomas E, Reeves Roger H, Richtsmeier Joan T

Abstract excerpt

Ts65Dn mice have segmental trisomy for orthologs of about half of the genes on human chromosome 21, including Ets2. These mice develop anomalies of the cranial skeleton and thymus that parallel those in Down syndrome. Overexpression of the Ets2 transcription factor gene was posited to be sufficie...

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Identifiers

PMID: 19764029
DOI: 10.1002/ajmg.a.33012
PMCID: PMC2903219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19764029-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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