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Article

Health consequences of mutant cartilage oligomeric matrix protein and its relationship to abnormal growth and joint degeneration.

Matrix biology : journal of the International Society for Matrix Biology - 1 May 2023

Hecht Jacqueline T, Chiu Frankie, Veerisetty Alka, Hossain Mohammad, Posey Karen L

Abstract excerpt

Cartilage oligomeric matrix protein (COMP), an extracellular matrix protein, has been shown to enhance proliferation and mechanical integrity in the matrix, supporting functions of the growth plate and articular cartilage. Mutations in COMP cause pseudoachondroplasia (PSACH), a severe dwarfing condition associated with premature joint degeneration and significant lifelong joint pain. The MT (mutant)-COMP mouse...

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Identifiers

PMID: 37001593
DOI: 10.1016/j.matbio.2023.03.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Health consequences of mutant cartilage oligomeric matrix protein and its relationship to abnormal growth and joint degeneration.PMID 37001593Read ↗

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