Article
Genetic polymorphisms in the estrogen receptor-α gene and the risk of endometrial cancer: a meta-analysis.
Acta obstetricia et gynecologica Scandinavica - 1 Aug 2012
Wang Yumei, Cui Meng, Zheng Liqiang
Abstract excerpt
Estrogen receptor-α is a key mediator of the estrogen response in endometrial tissue. The most-studied gene variants are the PvuII and XbaI polymorphisms, which may be associated with altered sensitivity to estrogen. However, studies evaluating the associations between these polymorphisms and endometrial cancer risk have produced controversial conclusions. To explore a more robust estimate of the role of estrogen...
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