Article
Association of insulin-like growth factor-1 receptor gene polymorphisms with left ventricular mass and geometry in essential hypertension.
Journal of human hypertension - 1 May 2010
Horio T, Kamide K, Takiuchi S, Yoshii M, Miwa Y, Matayoshi T, Yoshihara F, Nakamura S, Tokudome T, Miyata T, Kawano Y
Abstract excerpt
Stimulation of insulin-like growth factor (IGF)-1 receptor by IGF-1 and insulin strongly induces cardiomyocyte hypertrophy. In this study, we assessed the hypothesis that genetic variations of the IGF-1 receptor may be linked to the diversity of left ventricular (LV) structure in hypertensive patients. Genotypes in 12 single nucleotide polymorphisms (SNPs) of the IGF-1 receptor gene identified by direct...
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