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Neuropathy Target Esterase Is Required for Adult Vertebrate Axon Maintenance

16 Sept 2009

Abstract excerpt

The enzyme neuropathy target esterase (NTE) is present in neurons and deacylates the major membrane phospholipid, phosphatidylcholine (PtdCho). Mutation of the NTE gene or poisoning by neuropathic organophosphates--chemical inhibitors of NTE--causes distal degeneration of long spinal axons in humans. However, analogous neuropathological changes have not been reported in nestin-cre:NTEfl/fl mice with NTE-deficient...

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PMID: 19759306
DOI: 10.1523/jneurosci.3007-09.2009

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Neuropathy Target Esterase Is Required for Adult Vertebrate Axon MaintenancePMID 19759306Read ↗

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