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Article

Constructs of human neuropathy target esterase catalytic domain containing mutations related to motor neuron disease have altered enzymatic properties.

Toxicology letters - 1 Jul 2010

Hein Nichole D, Stuckey Jeanne A, Rainier Shirley R, Fink John K, Richardson Rudy J

Abstract excerpt

Neuropathy target esterase (NTE) is a phospholipase/lysophospholipase associated with organophosphorus (OP) compound-induced delayed neurotoxicity (OPIDN). Distal degeneration of motor axons occurs in both OPIDN and the hereditary spastic paraplegias (HSPs). Recently, mutations within the esterase domain of NTE were identified in patients with a novel type of HSP (SPG39) designated NTE-related motor neuron...

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Identifiers

PMID: 20382209
DOI: 10.1016/j.toxlet.2010.03.1120
PMCID: PMC4310459

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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