Article
The role of B cells in the pathogenesis of rheumatoid arthritis.
The Journal of rheumatology. Supplement - 1 Feb 2005
Kotzin Brian L
Abstract excerpt
The classical paradigm for rheumatoid arthritis (RA) pathogenesis holds that CD4+ T cells mediate joint damage both directly and by driving non-T effector cells to release inflammatory cytokines. By contrast, the new paradigm that is developing centers on an interaction of CD4+ T cells with B cells. Evidence reviewed in this article shows that autoreactive B cells can be driven by the T cells to produce IgG...
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