Enhancement of the cytotoxic activity of cytokine-induced killer cells transfected with IL3PE38KDEL gene against acute myeloid leukemia cells.

doi:10.1007/s00277-014-2146-5

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Enhancement of the cytotoxic activity of cytokine-induced killer cells transfected with IL3PE38KDEL gene against acute myeloid leukemia cells.

Annals of hematology - 1 Dec 2014

Shen Yan, Liu Qi, Luo Yun, Zhang Ping, Bai FengXia, Cheng ShiDi, Lou ShiFeng

Abstract excerpt

Cytokine-induced killer (CIK) cells, one of the feasible and effective methods of adoptive immunotherapy, have shown anti-leukemia activity in vivo and in vitro. But the strategy exhibits limited cytotoxic activity in clinical studies. In this study, CIK cells were transfected with an interleukin-3/Pseudomonas exotoxin gene (IL3PE38KDEL). RT-PCR and ELISA were used to verify the expression of IL3PE38KDEL in the...

Topics

ADP Ribose Transferases
Bacterial Toxins
Coculture Techniques
Cytokine-Induced Killer Cells
Cytotoxicity, Immunologic
Exotoxins
Genes, Synthetic
HL-60 Cells
Humans
Immunophenotyping
Immunotherapy
Interferon-gamma
Interleukin-3

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

K562 Cells

Leukemia, Myeloid, Acute

Mutation

Protein Structure, Tertiary

Pseudomonas aeruginosa

Source

Open in PubMed

Identifiers

PMID: 25029985
DOI: 10.1007/s00277-014-2146-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.