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Article

Genetic heterogeneity of polycystic kidney disease in Bulgaria.

Human genetics - 1 Jun 1995

Bogdanova N, Dworniczak B, Dragova D, Todorov V, Dimitrakov D, Kalinov K, Hallmayer J, Horst J, Kalaydjieva L

Abstract excerpt

Linkage analysis was performed on 22 Bulgarian families with polycystic kidney disease (PKD) ascertained through the hemodialysis centers of two medical schools. A total of 128 affected and 59 unaffected individuals, and 54 spouses have been investigated using eight polymorphic markers linked to PKD1 and nine markers to PKD2. The results demonstrate locus heterogeneity with 0.67 as the maximum likelihood value of...

Topics

Adult
Bulgaria
Data Collection
Female
Genetic Heterogeneity
Genetic Markers
Humans
Lod Score
Male
Middle Aged
Phenotype
Polycystic Kidney, Autosomal Dominant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

Proteins

Recombination, Genetic

TRPP Cation Channels

Source

Identifiers

PMID: 7789949
DOI: 10.1007/BF00209481

Genes

PKD1
PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7789949-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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