Article
Nucleocapsid protein of SARS-CoV activates the expression of cyclooxygenase-2 by binding directly to regulatory elements for nuclear factor-kappa B and CCAAT/enhancer binding protein.
The international journal of biochemistry & cell biology - 1 Jan 2006
Yan Xiaohong, Hao Qian, Mu Yongxin, Timani Khalid Amine, Ye Linbai, Zhu Ying, Wu Jianguo
Abstract excerpt
SARS-associated coronavirus (SARS-CoV) causes inflammation and damage to the lungs resulting in severe acute respiratory syndrome. To evaluate the molecular mechanisms behind this event, we investigated the roles of SARS-CoV proteins in regulation of the proinflammatory factor, cyclooxygenase-2 (COX-2). Individual viral proteins were tested for their abilities to regulate COX-2 gene expression. Results showed...
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