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Article

Distinct High-Profile Methylated Genes in Colorectal Cancer

10 Sept 2009

Abstract excerpt

BACKGROUND: Mutations and promoters' methylation of a set of candidate cancer genes (CAN genes) are associated with progression of colorectal cancer (CRC). We hypothesized that these genes' promoters are inactivated through epigenetic silencing and may show a different profile in high-risk populations. We investigated the status of CAN gene methylation and CHD5 protein expression in African American CRC tissue...

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PMID: 19750230
DOI: 10.1371/journal.pone.0007012

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