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Cell-based assays to identify inhibitors of viral disease

22 May 2008

Abstract excerpt

BACKGROUND: Antagonizing the production of infectious virus inside cells requires drugs that can cross the cell membrane without harming host cells. OBJECTIVE: It is therefore advantageous to establish intracellular potency of anti-viral drug candidates early in the drug-discovery pipeline. METHODS: To this end, cell-based assays are being developed and employed in high-throughput drug screening, ranging from...

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PMID: 19750206
DOI: 10.1517/17460441.3.6.671

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