Article
Improving power in genetic-association studies via wavelet transformation.
BMC genetics - 11 Sept 2009
Jiang Renfang, Dong Jianping, Dai Yilin
Abstract excerpt
BACKGROUND: A key to increasing the power of multilocus association tests is to reduce the number of degrees of freedom by suppressing noise from data. One of the difficulties is to decide how much noise to suppress. An often overlooked problem is that commonly used association tests based on genotype data cannot utilize the genetic information contained in spatial ordering of SNPs (see proof in the Appendix),...
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