Article
RNAi in budding yeast.
Science (New York, N.Y.) - 23 Oct 2009
Drinnenberg Ines A, Weinberg David E, Xie Kathleen T, Mower Jeffrey P, Wolfe Kenneth H, Fink Gerald R, Bartel David P
Abstract excerpt
RNA interference (RNAi), a gene-silencing pathway triggered by double-stranded RNA, is conserved in diverse eukaryotic species but has been lost in the model budding yeast Saccharomyces cerevisiae. Here, we show that RNAi is present in other budding yeast species, including Saccharomyces castellii and Candida albicans. These species use noncanonical Dicer proteins to generate small interfering RNAs, which mostly...
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