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Article

Sex-induced silencing defends the genome of Cryptococcus neoformans via RNAi.

Genes & development - 15 Nov 2010

Wang Xuying, Hsueh Yen-Ping, Li Wenjun, Floyd Anna, Skalsky Rebecca, Heitman Joseph

Abstract excerpt

Cosuppression is a silencing phenomenon triggered by the introduction of homologous DNA sequences into the genomes of organisms as diverse as plants, fungi, flies, and nematodes. Here we report sex-induced silencing (SIS), which is triggered by tandem integration of a transgene array in the human fungal pathogen Cryptococcus neoformans. A SXI2a-URA5 transgene array was found to be post-transcriptionally silenced...

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Identifiers

PMID: 21078820
DOI: 10.1101/gad.1970910
PMCID: PMC2975932

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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