Z and Mmalton-1-antitrypsin deficiency-associated hepatocellular carcinoma: a genetic study.

doi:10.1111/j.1478-3231.2009.02091.x

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Article

Z and Mmalton-1-antitrypsin deficiency-associated hepatocellular carcinoma: a genetic study.

Liver international : official journal of the International Association for the Study of the Liver - 1 Nov 2009

Francalanci Paola, Santorelli Filippo M, Saccani Simona, Bonetti Maria F, Medicina Daniela, Coni Pierpaolo, Faa Gavino, Callea Francesco

Abstract excerpt

BACKGROUND: The histological hallmark of alpha-1-antitrypsin deficiency (AATD) is the presence of periodic acid-Schiff diastase (PASD)-resistant positive globules in hepatocytes, with a heterogeneous distribution. It is noteworthy that hepatocellular carcinoma (HCC) arises specifically from the AAT-negative areas but the reason for this remains unclear. AIM: To determine whether the different distribution of AAT...

Topics

Carcinoma, Hepatocellular
Female
Genotype
Humans
Immunohistochemistry
Liver Neoplasms
Male
Middle Aged
alpha 1-Antitrypsin
alpha 1-Antitrypsin Deficiency

Source

Open in PubMed

Identifiers

PMID: 19744266
DOI: 10.1111/j.1478-3231.2009.02091.x

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