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Article

BRAF V600E mutation in biliary proliferations associated with α1 -antitrypsin deficiency.

Histopathology - 1 Feb 2017

Angkathunyakul Napat, Rosini Francesca, Heaton Nigel, Foskett Pierre, Quaglia Alberto

Abstract excerpt

AIMS: Both homozygous and heterozygous α1 -antitrypsin (AAT) deficiency patients are at risk of developing hepatocellular carcinoma (HCC), but also of developing cholangiocarcinoma and combined HCC and cholangiocarcinoma. The aim of our study is to report a series of bile duct adenomas (BDAs) and intrahepatic cholangiocarcinoma (ICCs) in adult AAT deficiency patients, observed in our institution over a 5-year...

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Share to alpha 1-Antitrypsin Deficiency
Share to Bile Duct Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bile Ducts, Intrahepatic

Share to Cholangiocarcinoma

Share to DNA Mutational Analysis

Share to Immunohistochemistry

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Share to Proto-Oncogene Proteins B-raf

Source

Identifiers

PMID: 27627051
DOI: 10.1111/his.13083

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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